The Ontology Profile tab is only visible if the selected resource
is an owl:Ontology. Use the "Home" button in the main tool bar to
switch to the owl:Ontology if needed.

The Profile tab can be used to select libraries of SPIN inferencing rules
and constraint checks for the current model.
One of those libraries is TopQuadrant's SPIN-based OWL 2 RL implementation.
The formal effect of activating a library is that the currently selected
owl:Ontology will point to that library using the property
spin:imports.
This information is used by the TopSPIN inference engine, and by the
SPIN constraint checking engine to dynamically add SPIN definitions to
the model. This is similar to using owl:imports to bring
the libraries in.
However, in contrast to owl:imports, the property spin:imports
does not load the imports at edit time, and thus does not lead to overly
complex models.